CRL was founded in 1996 at Ghent University, Belgium, as a research group within the VIB Department of Medical Protein Research.

Our team of 35 researchers combines extensive cell biology and molecular biology expertise and is housed in recently renovated laboratory facilities at the historic Rommelaere Institute.

Major research interests include leptin receptor activation and signalling and aspects of the innate immune response. Translational research is intrinsic to our programs, with possible applications in the fields of host defence and autoimmune disorders.

As a technology spin-off, we develop the MAPPIT and KISS two-hybrid traps to study interactions among proteins and between proteins and other molecules in living mammalian cells. Apart from applications in basic research, the MAPPIT technology suite provides valuable tools for drug discovery, including target identification, compound screening and lead profiling.

More recently, we are developing AcTakines, a novel class of immunocytokines to target cytokines to selected cell types.